Background :
@EN Neuropeptides are biologically active polypetides in sensory afferent nerve fibers and autonomic afferent nerve fibers, nerve fibers, where they coexist with neurotransmittes. In addition to the nurotransmitter or neuroendocrine role,
neuropeptides
play a role in mitogenic action in tissues and modulation in immune response. The cutaneous diseases which may be related to neuropeptides are psoiriasis, atopic dermatitis, chronic urticaria, postherpetic neuralgia, hemodialysis related
pruritus,
and
scleorderma.
@ES Objectives :
@EN We carried out tow kinds of experments to study the fole of neuropetides in poatherpetic neuralgia. Firstly, we investigated the occurrence and distrbution of substance P(SP), calcitonin gene relating peptide(CGRP), vasoactive intestinal
peptide(VIP), neuropeptide Y(NY), neurokinin A(NA), and somatostatin in normal human skin, provided the principal information needed to identify the neuropeptied role in several cutaneous diseases. Secondly, we compared the distribution of
neuropeptides
in normal skin and those in the ski of patients with postherpetic neuralgia.
@ES Methods :
@EN We used the indirect immunofluorescence staining method to achieve tow objectives mentioned above.
@ES Results :
@EN In almost all regions of normal human skin and the skin of patients with postherpetic neuralgia, significant amounts of SP, CGRP, VIP, NY, NA, and somatostatin immunoreactive nerve fibers(IRNF) were found. CGRP, VIP, and NY IRNF were more
frequently
observed around swe4at glands and blood vessels. Only VIP IRNF were found occasionally in the epidermis.
@ES Conclusion :
@EN There was no difference between the neuropeptides IRNF of the skin from patients with postherpetic neuralgia and those of the normal skin except the absence of VIP IRNF in patients with postherpetic neuralgia. (Kor J Dermatol 1996;34(1) :
273~278)
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